Pre-emptive analgesia with NSAID-what does it achieve?
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چکیده
منابع مشابه
Pre-emptive analgesia with NSAID--what does it achieve?
Sir,—We wish to comment on the study of Espinet and colleagues [1] who investigated the combined effect of thoracic extradural local anaesthetic block and administration of diclofenac either 30 min before or 30 min after skin incision on post-hysterectomy pain and analgesic consumption. They found that the timing of analgesia made no difference to pain scores or postoperative analgesic requirem...
متن کاملPre-emptive analgesia.
Transmission of pain signals evoked by tissue damage leads to sensitization of the peripheral and central pain pathways. Pre-emptive analgesia is a treatment that is initiated before the surgical procedure in order to reduce this sensitization. Owing to this 'protective' effect on the nociceptive system, pre-emptive analgesia has the potential to be more effective than a similar analgesic treat...
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5. Mallett SV, RoUes K, Cox D, Burroughs A, Hunt B. Intraopcrative use of aprotinin (Trasylol) in orthotopic liver transplantation. Transplantation Proceedings 1991; 23: 19311932. 6. Thomson JF, Roath OS, Francis JL, Webster JHM, Chant ADB. Aprotinin in peripheral vascular surgery. Lancet 1990; 335:911. 7. Kobrinsky NL, Letts MR, Patcl LR, l-Desamino-8-D arginine vasopressine (Desmopressin) dec...
متن کاملWhat is the role of NSAIDs in pre-emptive analgesia?
NSAIDs inhibit the cyclo-oxygenase enzymes, and decrease peripheral and central prostaglandin production. In addition to reducing the inflammation that accompanies tissue injury, decreasing prostaglandin production attenuates the response of the peripheral and central components of the nervous system to noxious stimuli. Such a reduction in the response to pain can reduce the peripheral and cent...
متن کاملExperimental pre-emptive analgesia: what value for the clinician?
writing yet another editorial on pre-emptive analgesia when extensive editorials and reviews1–4 have been published within less than a year, and even in this Journal.5 In fact, pre-emptive analgesia is such a complex and controversial topic that it can be viewed from many different aspects. I would like to consider the significance of experimental results, like the ones reported by Nakamura and...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1996
ISSN: 0007-0912
DOI: 10.1093/bja/77.1.128